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It is well-known that calorie restriction triggers youthful gene expression – the process by which genes transmit signals that slow certain aspects of aging. Essentially, calorie restriction provides anti-aging benefits. In 2003 Life Extension introduced standardised extract of resveratrol, and in 2009 pterostilbene - a stilbenoid like resveratrol - which is thought to have the ability to inhibit and reverse cognitive decline. Resveratrol and pterostilbene have been found to work synergistically to activate longevity genes, thus working as an anti-aging supplement.
CR Mimetic Longevity Formula is an anti-aging supplement that contains the five known calorie-restriction mimetics - transresveratrol, transpterotilbene, quercetin, grape-seed polyphenols and black tea extract, to which a sixth has now been added - the flavonol fisetin. Fisetin belongs to the flavonoid group of polyphenols and is found in many plants, fruits and vegetables, such as strawberries, apples, persimmons, onions and cucumbers and is likewise thought to be a calorie restriction mimetic. Fisetin may also have resveratrol-enhancing effects. Research has indicated that fisetin can stabilise resveratrol by protecting it from metabolic breakdown and thus extending its anti-aging effects.
Apart from its calorie restriction mimetic and thus anti-aging qualities, fisetin has powerful natural antioxidant effects which may be due both to its structural properties and to its ability to modulate certain cellular signalling pathways leading to increased expression of several protective and antioxidant genes. Fisetin also provides neuroprotection in the presence of oxidative stress.
Each anti-aging capsule serving (2 x capsules) contains the same amount of fisetin as two cups (about 250g) of strawberries, thus contributing to the calorie-restriction effect on longevity genes.
CR Mimetic Longevity Formula anti-aging supplements can be ordered online. Prompt delivery assured.
Serving size 2 vegetarian capsules
Servings Per Container 30
Amount per Serving
Trans-Resveratrol [from Japanese knotweed extract (root)] 250mg
Trans-Pterostilbene (from pTeroPure®) 3 mg
Quercetin (as quercetin dihydrate) 150 mg
Masquelier’s® Original OPCs [single and condensed (2-5 units) of flavanols & polyphenols from grape seeds] 50 mg
Black tea decaffeinated extract (leaf) [standardised to 12% TF2a theaflavin fraction (36 mg), along with TF1, TF2b and TF3 theaflavin fractions] 300 mg
Fisetin [from wax tree extract (stem)] 48 mg
Other ingredients: vegetable cellulose (capsule), microcrystalline cellulose, silica, vegetable stearate.
TeroPure® is a registered trademark of ChromaDex, Inc.
MASQUELIER’s® is a registered trademark of International Nutrition Company BV (INC), Loosdrecht, The Netherlands.
Dosage and Use